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M9630248.TXT
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1996-02-27
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Document 0248
DOCN M9630248
TI The diagnostic value of morphometry on blood lymphocytes in
erythrodermic actinic reticuloid.
DT 9603
AU Preesman AH; Schrooyen SJ; Toonstra J; van der Putte SC; Rademakers LH;
Willemze R; van Vloten WA; Department of Dermatology, University
Hospital Utrecht, The; Netherlands.
SO Arch Dermatol. 1995 Nov;131(11):1298-303. Unique Identifier : AIDSLINE
MED/96067817
AB BACKGROUND: As the differential diagnosis of erythrodermic actinic
reticuloid vs Sezary syndrome (SS) can be very difficult, we examined
the value of the nuclear contour index (NCI) on blood lymphocytes as the
criterion for differential diagnoses. The NCI is defined as the nuclear
parameter divided by the square root of the nuclear area. Three
different parameters were studied: mean NCI, percentage of cells with an
NCI of 6.5 or greater, and the highest NCI. These indexes were studied
on blood lymphocyte samples obtained from 10 patients with erythrodermic
actinic reticuloid and were compared with the findings in 10 patients
with other benign forms of erythroderma and in seven patients suffering
from SS. RESULTS: The patients with erythrodermic actinic reticuloid
differed significantly from the group with SS regarding the percentage
of cells with an NCI of 6.5 or greater and the highest NCI, but not when
the mean NCI was considered. All three parameters revealed
nonsignificant results for erythrodermic actinic reticuloid compared
with other benign forms of erythroderma. The group with SS differed
significantly from the patients with other benign forms of erythroderma
regarding all three parameters. By combining three morphometric criteria
(mean NCI, > or = 5.5; > 30% lymphoid cells with an NCI of > or = 6.5;
and highest NCI, > or = 11.5), all patients with erythrodermic actinic
reticuloid or other benign forms of erythroderma and six of the seven
patients with SS were correctly classified. CONCLUSION: Our data
indicate that assessment of the NCI on peripheral blood lymphocytes is
of value in the differential diagnosis of erythrodermic actinic
reticuloid vs SS.
DE Aged Aged, 80 and over Cell Nucleus/*PATHOLOGY Comparative Study
CD4-CD8 Ratio Dermatitis, Exfoliative/BLOOD/DIAGNOSIS Diagnosis,
Differential Female Follow-Up Studies Human Lymphocytes/*PATHOLOGY
Male Middle Age Photosensitivity Disorders/*BLOOD/*DIAGNOSIS Sezary
Syndrome/BLOOD/DIAGNOSIS Skin Neoplasms/BLOOD/DIAGNOSIS CLINICAL TRIAL
JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).